Prof. Dr. med Ulrich Bogdahn
Chief Medical Officer
Clinical therapy development expert with competencies in Neuro-oncology, Stem-Cells, Neuroimaging & Drug-Discovery, >300 publications and patents, and total of >EUR 25m in grant money raised.
career
| Since 2012 | Project-Head CampoNeuro, NVP-13 (BioM Biotech, GO-Bio), Regensburg |
| 1995-2017 | Chairman Dpt. Neurology University of Regensburg |
| 1982-1983 | Postdoc at UCSF, San Francisco |
| 1978-1994 | Dpt. Neurology University of Würzburg (Prof. H.G. Mertens) |
Publications
Sandner, B.; Rivera, F.; Caioni, M.; Nicholson, L.S.; Eckstein, V.; Bogdahn, U.; Aigner, L.; Blesch, A.; Weidner, N. Bone morphogenetic proteins prevent bone marrow stromal cell-mediated oligodendroglial differentiation of transplanted adult neural progenitor cells in the injured spinal cord. Stem cell research 2013, 11, 758-71, doi:10.1016/j.scr.2013.05.003.
Blume, J.; Rothenfusser, E.; Schlaier, J.; Bogdahn, U.; Lange, M. Educational attainment and motor burden in advanced Parkinson's disease - The emerging role of education in motor reserve. Journal of the neurological sciences 2017, 381, 141-143, doi:10.1016/j.jns.2017.08.3241.
Hau, P.; Jachimczak, P.; Bogdahn, U. Treatment of malignant gliomas with TGF-beta2 antisense oligonucleotides. Expert review of anticancer therapy 2009, 9, 1663-74, doi:10.1586/era.09.138.
Seliger, C.; Meier, C.; Becker, C.; Jick, S.; Bogdahn, U.; Hau, P.; Leitzmann, M. Use of Selective Cyclooxygenase-2 Inhibitors, Other Analgesics, and Risk of Glioma. PloS one 2016, 11, e0149293, doi:10.1371/journal.pone.0149293.
Hau, P.; Jachimczak, P.; Schlingensiepen, R.; Schulmeyer, F.; Jauch, T.; Steinbrecher, A.; Brawanski, A.; Proescholdt, M.; Schlaier, J.; Buchroithner, J.; et al. Inhibition of TGF-beta2 with AP 12009 in recurrent malignant gliomas: from preclinical to phase I/II studies. Oligonucleotides 2007, 17, 201-12.
Sander, P.; Hau, P.; Koch, S.; Schütze, K.; Bogdahn, U.; Kalbitzer, H.; Aigner, L. Stem cell metabolic and spectroscopic profiling. Trends in biotechnology 2013, 31, 204-13, doi:10.1016/j.tibtech.2013.01.008.
Leidgens, V.; Proske, J.; Rauer, L.; Moeckel, S.; Renner, K.; Bogdahn, U.; Riemenschneider, M.; Proescholdt, M.; Vollmann-Zwerenz, A.; Hau, P.; et al. Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation. Oncotarget 2017, 8, 8250-8263, doi:10.18632/oncotarget.14159.
Beier, C.; Schmid, C.; Gorlia, T.; Kleinletzenberger, C.; Beier, D.; Grauer, O.; Steinbrecher, A.; Hirschmann, B.; Brawanski, A.; Dietmaier, C.; et al. RNOP-09: pegylated liposomal doxorubicine and prolonged temozolomide in addition to radiotherapy in newly diagnosed glioblastoma--a phase II study. BMC cancer 2009, 9, 308, doi:10.1186/1471-2407-9-308.
Hasan, M.; Neumann, B.; Haupeltshofer, S.; Stahlke, S.; Fantini, M.; Angstwurm, K.; Bogdahn, U.; Kleiter, I. Activation of TGF-β-induced non-Smad signaling pathways during Th17 differentiation. Immunology and cell biology 2015, 93, 662-72, doi:10.1038/icb.2015.21.
Vroemen, M.; Caioni, M.; Bogdahn, U.; Weidner, N. Failure of Schwann cells as supporting cells for adult neural progenitor cell grafts in the acutely injured spinal cord. Cell and tissue research 2007, 327, 1-13.
Beier, C.; Kumar, P.; Meyer, K.; Leukel, P.; Bruttel, V.; Aschenbrenner, I.; Riemenschneider, M.; Fragoulis, A.; Rümmele, P.; Lamszus, K.; et al. The cancer stem cell subtype determines immune infiltration of glioblastoma. Stem cells and development 2012, 21, 2753-61, doi:10.1089/scd.2011.0660.
Seliger, C.; Meier, C.; Becker, C.; Jick, S.; Proescholdt, M.; Bogdahn, U.; Hau, P.; Leitzmann, M. Metabolic syndrome in relation to risk of meningioma. Oncotarget 2017, 8, 2284-2292, doi:10.18632/oncotarget.13667.
Baumann, F.; Leukel, P.; Doerfelt, A.; Beier, C.; Dettmer, K.; Oefner, P.; Kastenberger, M.; Kreutz, M.; Nickl-Jockschat, T.; Bogdahn, U.; et al. Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2. Neuro-oncology 2009, 11, 368-80, doi:10.1215/15228517-2008-106.
Kandasamy, M.; Rosskopf, M.; Wagner, K.; Klein, B.; Couillard-Despres, S.; Reitsamer, H.; Stephan, M.; Nguyen, H.; Riess, O.; Bogdahn, U.; et al. Reduction in subventricular zone-derived olfactory bulb neurogenesis in a rat model of Huntington's disease is accompanied by striatal invasion of neuroblasts. PloS one 2015, 10, e0116069, doi:10.1371/journal.pone.0116069.
Rivera, F.; Couillard-Despres, S.; Pedré, X.; Ploetz, S.; Caioni, M.; Lois, C.; Bogdahn, U.; Aigner, L. Mesenchymal stem cells instruct oligodendrogenic fate decision on adult neural stem cells. Stem cells (Dayton, Ohio) 2006, 24, 2209-19.
Ramm, P.; Bettscheider, M.; Beier, D.; Kalbitzer, H.; Kremer, W.; Bogdahn, U.; Hau, P.; Aigner, L.; Beier, C. 1H-nuclear magnetic resonance spectroscopy of glioblastoma cancer stem cells. Stem cells and development 2011, 20, 2189-95, doi:10.1089/scd.2010.0567.
Peters, S.; Zitzelsperger, E.; Kuespert, S.; Iberl, S.; Heydn, R.; Johannesen, S.; Petri, S.; Aigner, L.; Thal, D.R.; Hermann, A.; et al. The TGF-β System As a Potential Pathogenic Player in Disease Modulation of Amyotrophic Lateral Sclerosis. Frontiers in neurology 2017, 8, 669, doi:10.3389/fneur.2017.00669.
Ramm, P.; Couillard-Despres, S.; Plötz, S.; Rivera, F.; Krampert, M.; Lehner, B.; Kremer, W.; Bogdahn, U.; Kalbitzer, H.; Aigner, L. A nuclear magnetic resonance biomarker for neural progenitor cells: is it all neurogenesis? Stem cells (Dayton, Ohio) 2009, 27, 420-3, doi:10.1634/stemcells.2008-0816.
Leidgens, V.; Seliger, C.; Jachnik, B.; Welz, T.; Leukel, P.; Vollmann-Zwerenz, A.; Bogdahn, U.; Kreutz, M.; Grauer, O.; Hau, P. Ibuprofen and Diclofenac Restrict Migration and Proliferation of Human Glioma Cells by Distinct Molecular Mechanisms. PloS one 2015, 10, e0140613, doi:10.1371/journal.pone.0140613.
Wachs, F.-P.; Winner, B.; Couillard-Despres, S.; Schiller, T.; Aigner, R.; Winkler, J.; Bogdahn, U.; Aigner, L. Transforming growth factor-beta1 is a negative modulator of adult neurogenesis. Journal of neuropathology and experimental neurology 2006, 65, 358-70.
Hau, P.; Jachimczak, P.; Schlaier, J.; Bogdahn, U. TGF-β2 signaling in high-grade gliomas. Current pharmaceutical biotechnology 2011, 12, 2150-7.
Baldaranov, D.; Khomenko, A.; Kobor, I.; Bogdahn, U.; Gorges, M.; Kassubek, J.; Müller, H.-P. Longitudinal Diffusion Tensor Imaging-Based Assessment of Tract Alterations: An Application to Amyotrophic Lateral Sclerosis. Frontiers in human neuroscience 2017, 11, 567, doi:10.3389/fnhum.2017.00567.
Rivera, F.; Siebzehnrubl, F.; Kandasamy, M.; Couillard-Despres, S.; Caioni, M.; Poehler, A.-M.; Berninger, B.; Sandner, B.; Bogdahn, U.; Goetz, M.; et al. Mesenchymal stem cells promote oligodendroglial differentiation in hippocampal slice cultures. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009, 24, 317-24, doi:10.1159/000233256.
Wallner, S.; Peters, S.; Pitzer, C.; Resch, H.; Bogdahn, U.; Schneider, A. The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity. Frontiers in cell and developmental biology 2015, 3, 48, doi:10.3389/fcell.2015.00048.
Stupp, R.; Mason, W.; van den Bent, M.; Weller, M.; Fisher, B.; Taphoorn, M.; Belanger, K.; Brandes, A.; Marosi, C.; Bogdahn, U.; et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. The New England journal of medicine 2005, 352, 987-96.
Kuespert, S.; Heydn, R.; Peters, S.; Wirkert, E.; Meyer, A.-L.; Siebörger, M.; Johannesen, S.; Aigner, L.; Bogdahn, U.; Bruun, T.-H. Antisense Oligonucleotide in LNA-Gapmer Design Targeting TGFBR2-A Key Single Gene Target for Safe and Effective Inhibition of TGFβ Signaling. International journal of molecular sciences 2020, 21, doi:10.3390/ijms21061952.
Pillai, D.; Heidemann, R.; Kumar, P.; Shanbhag, N.; Lanz, T.; Dittmar, M.; Sandner, B.; Beier, C.; Weidner, N.; Greenlee, M.W.; et al. Comprehensive small animal imaging strategies on a clinical 3 T dedicated head MR-scanner; adapted methods and sequence protocols in CNS pathologies. PloS one 2011, 6, e16091, doi:10.1371/journal.pone.0016091.
Seliger, C.; Meier, C.; Becker, C.; Jick, S.; Bogdahn, U.; Hau, P.; Leitzmann, M. Statin use and risk of glioma: population-based case-control analysis. European journal of epidemiology 2016, 31, 947-52, doi:10.1007/s10654-016-0145-7.
Rivera, F.; Kandasamy, M.; Couillard-Despres, S.; Caioni, M.; Sanchez, R.; Huber, C.; Weidner, N.; Bogdahn, U.; Aigner, L. Oligodendrogenesis of adult neural progenitors: differential effects of ciliary neurotrophic factor and mesenchymal stem cell derived factors. Journal of neurochemistry 2008, 107, 832-43, doi:10.1111/j.1471-4159.2008.05674.x.
Marschallinger, J.; Krampert, M.; Couillard-Despres, S.; Heuchel, R.; Bogdahn, U.; Aigner, L. Age-dependent and differential effects of Smad7ΔEx1 on neural progenitor cell proliferation and on neurogenesis. Experimental gerontology 2014, 57, 149-54, doi:10.1016/j.exger.2014.05.011.
Draganski, B.; Gaser, C.; Busch, V.; Schuierer, G.; Bogdahn, U.; May, A. Neuroplasticity: changes in grey matter induced by training. Nature 2004, 427, 311-2.
Wirth, A.M.; Johannesen, S.; Khomenko, A.; Baldaranov, D.; Bruun, T.-H.; Wendl, C.; Schuierer, G.; Greenlee, M.W.; Bogdahn, U. Value of fluid-attenuated inversion recovery MRI data analyzed by the lesion segmentation toolbox in amyotrophic lateral sclerosis. Journal of magnetic resonance imaging : JMRI 2019, 50, 552-559, doi:10.1002/jmri.26577.
Kandasamy, M.; Reilmann, R.; Winkler, J.; Bogdahn, U.; Aigner, L. Transforming Growth Factor-Beta Signaling in the Neural Stem Cell Niche: A Therapeutic Target for Huntington's Disease. Neurology research international 2011, 2011, 124256, doi:10.1155/2011/124256.
Seliger, C.; Meyer, A.-L.; Renner, K.; Leidgens, V.; Moeckel, S.; Jachnik, B.; Dettmer, K.; Tischler, U.; Gerthofer, V.; Rauer, L.; et al. Metformin inhibits proliferation and migration of glioblastoma cells independently of TGF-β2. Cell cycle (Georgetown, Tex.) 2016, 15, 1755-66, doi:10.1080/15384101.2016.1186316.
Beier, D.; Wischhusen, J.; Dietmaier, W.; Hau, P.; Proescholdt, M.; Brawanski, A.; Bogdahn, U.; Beier, C. CD133 expression and cancer stem cells predict prognosis in high-grade oligodendroglial tumors. Brain pathology (Zurich, Switzerland) 2008, 18, 370-7, doi:10.1111/j.1750-3639.2008.00130.x.
Kandasamy, M.; Lehner, B.; Kraus, S.; Sander, P.; Marschallinger, J.; Rivera, F.; Trümbach, D.; Ueberham, U.; Reitsamer, H.; Strauss, O.; et al. TGF-beta signalling in the adult neurogenic niche promotes stem cell quiescence as well as generation of new neurons. Journal of cellular and molecular medicine 2014, 18, 1444-59, doi:10.1111/jcmm.12298.
Peters, S.; Kuespert, S.; Wirkert, E.; Heydn, R.; Jurek, B.; Johannesen, S.; Hsam, O.; Korte, S.; Ludwig, F.; Mecklenburg, L.; et al. Reconditioning the Neurogenic Niche of Adult Non-human Primates by Antisense Oligonucleotide-Mediated Attenuation of TGFβ Signaling. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2021, doi:10.1007/s13311-021-01045-2.
Iberl, S.; Meyer, A.-L.; Müller, G.; Peters, S.; Johannesen, S.; Kobor, I.; Beier, F.; Brümmendorf, T.; Hart, C.; Schelker, R.; et al. Effects of continuous high-dose G-CSF administration on hematopoietic stem cell mobilization and telomere length in patients with amyotrophic lateral sclerosis - a pilot study. Cytokine 2019, 120, 192-201, doi:10.1016/j.cyto.2019.05.003.
Kandasamy, M.; Couillard-Despres, S.; Raber, K.; Stephan, M.; Lehner, B.; Winner, B.; Kohl, Z.; Rivera, F.; Nguyen, H.; Riess, O.; et al. Stem cell quiescence in the hippocampal neurogenic niche is associated with elevated transforming growth factor-beta signaling in an animal model of Huntington disease. Journal of neuropathology and experimental neurology 2010, 69, 717-28, doi:10.1097/NEN.0b013e3181e4f733.
Dubinski, D.; Wölfer, J.; Hasselblatt, M.; Schneider-Hohendorf, T.; Bogdahn, U.; Stummer, W.; Wiendl, H.; Grauer, O. CD4+ T effector memory cell dysfunction is associated with the accumulation of granulocytic myeloid-derived suppressor cells in glioblastoma patients. Neuro-oncology 2016, 18, 807-18, doi:10.1093/neuonc/nov280.
Winner, B.; Rockenstein, E.; Lie, C.; Aigner, R.; Mante, M.; Bogdahn, U.; Couillard-Despres, S.; Masliah, E.; Winkler, J. Mutant alpha-synuclein exacerbates age-related decrease of neurogenesis. Neurobiology of aging 2008, 29, 913-25.
Grassinger, J.; Khomenko, A.; Hart, C.; Baldaranov, D.; Johannesen, S.; Mueller, G.; Schelker, R.; Schulte-Mattler, W.; Andreesen, R.; Bogdahn, U. Safety and feasibility of long term administration of recombinant human granulocyte-colony stimulating factor in patients with amyotrophic lateral sclerosis. Cytokine 2014, 67, 21-8, doi:10.1016/j.cyto.2014.02.003.
Peters, S.; Wirkert, E.; Kuespert, S.; Heydn, R.; Johannesen, S.; Friedrich, A.; Mailänder, S.; Korte, S.; Mecklenburg, L.; Aigner, L.; et al. Safe and Effective Cynomolgus Monkey GLP-Tox Study with Repetitive Intrathecal Application of a TGFBR2 Targeting LNA-Gapmer Antisense Oligonucleotide as Treatment Candidate for Neurodegenerative Disorders. Pharmaceutics 2022, 14, doi:10.3390/pharmaceutics14010200.
Beier, D.; Proescholdt, M.; Reinert, C.; Pietsch, T.; Jones, D.; Pfister, S.; Hattingen, E.; Seidel, C.; Dirven, L.; Luerding, R.; et al. Multicenter pilot study of radiochemotherapy as first-line treatment for adults with medulloblastoma (NOA-07). Neuro-oncology 2018, 20, 400-410, doi:10.1093/neuonc/nox155.
Krampert, M.; Chirasani, S.; Wachs, F.-P.; Aigner, R.; Bogdahn, U.; Yingling, J.; Heldin, C.-H.; Aigner, L.; Heuchel, R. Smad7 regulates the adult neural stem/progenitor cell pool in a transforming growth factor beta- and bone morphogenetic protein-independent manner. Molecular and cellular biology 2010, 30, 3685-94, doi:10.1128/MCB.00434-09.
Stein, F.; Kobor, I.; Bogdahn, U.; Schulte-Mattler, W. Toward the validation of a new method (MUNIX) for motor unit number assessment. Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology 2016, 27, 73-7, doi:10.1016/j.jelekin.2016.02.001.
Couillard-Despres, S.; Quehl, E.; Altendorfer, K.; Karl, C.; Ploetz, S.; Bogdahn, U.; Winkler, J.; Aigner, L. Human in vitro reporter model of neuronal development and early differentiation processes. BMC neuroscience 2008, 9, 31, doi:10.1186/1471-2202-9-31.
Seliger, C.; Leukel, P.; Moeckel, S.; Jachnik, B.; Lottaz, C.; Kreutz, M.; Brawanski, A.; Proescholdt, M.; Bogdahn, U.; Bosserhoff, A.-K.; et al. Lactate-modulated induction of THBS-1 activates transforming growth factor (TGF)-beta2 and migration of glioma cells in vitro. PloS one 2013, 8, e78935, doi:10.1371/journal.pone.0078935.
Kozole, J.; Heydn, R.; Wirkert, E.; Küspert, S.; Aigner, L.; Bruun, T.-H.; Bogdahn, U.; Peters, S.; Johannesen, S. Direct Potential Modulation of Neurogenic Differentiation Markers by Granulocyte-Colony Stimulating Factor (G-CSF) in the Rodent Brain. Pharmaceutics 2022, 14, doi:10.3390/pharmaceutics14091858.
Wirth, A.M.; Khomenko, A.; Baldaranov, D.; Kobor, I.; Hsam, O.; Grimm, T.; Johannesen, S.; Bruun, T.-H.; Schulte-Mattler, W.; Greenlee, M.W.; et al. Combinatory Biomarker Use of Cortical Thickness, MUNIX, and ALSFRS-R at Baseline and in Longitudinal Courses of Individual Patients With Amyotrophic Lateral Sclerosis. Frontiers in neurology 2018, 9, 614, doi:10.3389/fneur.2018.00614.
Kandasamy, M.; Couillard-Despres, S.; Raber, K.; Stephan, M.; Lehner, B.; Winner, B.; Kohl, Z.; Rivera, F.; Nguyen, H.; Riess, O.; et al. Stem cell quiescence in the hippocampal neurogenic niche is associated with elevated transforming growth factor-beta signaling in an animal model of Huntington disease. Journal of neuropathology and experimental neurology 2010, 69, 717-28, doi:10.1097/NEN.0b013e3181e4f733.
Kirzinger, L.; Boy, S.; Marienhagen, J.; Schuierer, G.; Neu, R.; Ried, M.; Hofmann, H.-S.; Wiebe, K.; Ströbel, P.; May, C.; et al. Octreotide LAR and Prednisone as Neoadjuvant Treatment in Patients with Primary or Locally Recurrent Unresectable Thymic Tumors: A Phase II Study. PloS one 2016, 11, e0168215, doi:10.1371/journal.pone.0168215.
Aigner, L.; Bogdahn, U. TGF-beta in neural stem cells and in tumors of the central nervous system. Cell and tissue research 2008, 331, 225-41.
Kraus, S.; Lehner, B.; Reichhart, N.; Couillard-Despres, S.; Wagner, K.; Bogdahn, U.; Aigner, L.; Strauß, O. Transforming growth factor-β1 primes proliferating adult neural progenitor cells to electrophysiological functionality. Glia 2013, 61, 1767-83, doi:10.1002/glia.22551.
Peters, S.; Wirkert, E.; Kuespert, S.; Heydn, R.; Korte, S.; Mecklenburg, L.; Aigner, L.; Johannesen, S.; Bruun, T.-H.; Bogdahn, U. Targeting TGF-ß in the Central Nervous System: Assessment of Cynomolgus Monkey—Toxicity and Pharmacokinetics for an LNA-Antisense Oligonucleotide. Applied Sciences 2022, doi:https://doi.org/10.3390/app12030973.
Johannesen, S.; Budeus, B.; Peters, S.; Iberl, S.; Meyer, A.-L.; Kammermaier, T.; Wirkert, E.; Bruun, T.-H.; Samara, V.C.; Schulte-Mattler, W.; et al. Biomarker Supervised G-CSF (Filgrastim) Response in ALS Patients. Frontiers in neurology 2018, 9, 971, doi:10.3389/fneur.2018.00971.
Kleiter, I.; Song, J.; Lukas, D.; Hasan, M.; Neumann, B.; Croxford, A.; Pedré, X.; Hövelmeyer, N.; Yogev, N.; Mildner, A.; et al. Smad7 in T cells drives T helper 1 responses in multiple sclerosis and experimental autoimmune encephalomyelitis. Brain : a journal of neurology 2010, 133, 1067-81, doi:10.1093/brain/awq039.
Moeckel, S.; Vollmann-Zwerenz, A.; Proescholdt, M.; Brawanski, A.; Riemenschneider, M.; Bogdahn, U.; Bosserhoff, A.-K.; Spang, R.; Hau, P. Validation Study: Response-Predictive Gene Expression Profiling of Glioma Progenitor Cells In Vitro. PloS one 2016, 11, e0151312, doi:10.1371/journal.pone.0151312.
Kleiter, I.; Pedré, X.; Mueller, A.; Poeschl, P.; Couillard-Despres, S.; Spruss, T.; Bogdahn, U.; Giegerich, G.; Steinbrecher, A. Inhibition of Smad7, a negative regulator of TGF-beta signaling, suppresses autoimmune encephalomyelitis. Journal of neuroimmunology 2007, 187, 61-73.
